Nasal delivery is a choice of treatment or drug
delivery for the topical treatment of nasal diseases and paranasal
sinuses like sinusitis and allergic rhinitis. Moreover, the nasal
route is considered in some cases over the normal oral route owing to
rapid absorption and needle-free drug delivery with the effect as
desired. Hence, it is also one of the preferred routes for
needle-free vaccination and systemic drug delivery. Moreover, this
route helps addressing issues related to poor bioavailability, slow
absorption, drug degradation and adverse events in the
gastrointestinal tract. Atomized nasal medications rapidly absorb
across mucosal membranes into the bloodstream, avoiding first-pass
metabolism. However, during nasal delivery one needs to take care to
protect the delicate lungs from hazardous exposures. Medication in
liquid form can be administered via nasal route through inhalers,
spray pumps, droppers, nebulizers or atomizers. In atomizers the
medication exits the tip as a fine atomized mist resulting in broad
coverage of the nasal mucosal with a thin layer of drug.
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Nasal Atomizer Device Types
Nasal atomizers are currently used in the
treatment of allergic rhinitis and sinusitis. These devices usually
are multi-dose products enabling long-term usage of the device. The
nasal atomizers are classified based on the technology/mechanics as
gas propelled or electrical. The air or gas controlled technique
involves the use of squeezed bottle which when pressed releases the
content out of the small nozzle in definite volume. The dose
delivered however is highly dependent on the pressure applied while
squeezing the bottle. An electronic atomizer on the other hand is
devised to release only a defined amount of medication from the
nozzle. This makes the use of device more convenient for patients at
home.
Kurve Technology had designed and developed a
nasal drug delivery device called ViaNase in 2004 that used a
controlled particle dispersion method. During that period, Kurve’s
technology was the only known technique that delivered chemical
formulations via the nose to the paranasal sinuses in clinical
testing. Moreover, Kurve’s technology was also designed to be used
with multiple drugs.
Accurate Dosing is Essential in
Atomization
Since then there have been many new devices being
introduced in the market with improving dosage accuracy. Accurate
dosing is essential in a nasal atomization device to circumvent any
side effects due to overdose. Recently in November 2016, Teleflex
Medical Corporation recalled its MAD Nasal Intranasal Mucosal
atomization device which contained drug to reverse the action of
opioid overdose. The device was recalled on the warning that it may
not deliver the proper dose of the drug naloxone hydrochloride. This
drug with the device is extensively used by the policemen and
firefighters in the U.S.
The market still in its nascent stages of adoption
is experiencing increasing acceptance in the developed regions of
North America and Europe. However, creating awareness among the
healthcare professionals and patients is essential for acceptance of
this novel technology. Increasing self-medication trend can be
leveraged upon for penetrating the global nasal drug delivery devices
market.
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Major market players include DeVilbiss
Healthcare, Teleflex Incorporated, and Kurve Technology, etc. Being a
niche segment of drug delivery, there exists a lot potential for
manufacturers of nasal drug delivery systems.
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