Protein A is a bacterial protein, which has
capacity to bind mammalian antibodies of class immunoglobulin G with
great affinity. Protein G binds to all subclasses of human
immunoglobulin G (IgG) makes it useful for purifying polyclonal or
monoclonal IgG antibodies whose subclasses have not been determined.
Monoclonal antibodies are defined as ‘an antibody produced by a
single clone of cells'. It can be used to carry drugs, toxins, or
radioactive substances traditional to cancer cells. Monoclonal
antibodies have been showing promising results in the management of
chronic diseases such as cancers and rheumatoid arthritis. These are
essential and are broadly used as purification and separation
materials due to high resolution, across the biopharmaceutical
industry. Natural protein A can be produced from Staphylococcus
aureus, though protein A is now commonly produced recombinant in
Escherichia coli. Chromatography with these has several
advantages as a separation method, over conventional techniques such
as solvent extraction, crystallization, and distillation.
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Increasing diagnostic and therapeutic applications
of monoclonal antibodies in management of chronic diseases such as
cancer, rheumatoid arthritis beside with increasing R&D
activities on monoclonal antibodies will drive protein A resins
market over the forecast period. High selectivity and improved
antibody production coupled with ease of operation in large and small
scale antibody purification and immunoprecipitation will further
drive growth of the protein A resins market growth. Encouraging
government policies in terms of formulation of suitable policies for
startups and administration of funding for development of next-gen
medical products are expected to play a vital role in driving growth.
Development of cost effective protein A resin is also expected to
boost growth of the market.
Protein A Resin Market
On the basis of Product, the protein A resin
market is classified into:
-
Natural Protein A Resin
-
Recombinant Protein A Resin
On the basis of Application, the protein A resin
market is classified into:
-
Immunoprecipitation
-
Antibody Purification
On the basis of Matrix Type, the protein A resins
is classified into:
-
Glass or Silica
-
Agarose and
-
Organic Polymer
On the basis of end users, the protein A resins is
classified into:
-
Biopharmaceutical Manufacturers
-
Clinical Research Laboratories and
-
Academic Institutions
Geographically, North America accounted for the
leading share in the global protein A resin market, due to the large
number of clinical trials for the monoclonal antibody based
therapeutics and increasing traction for biosimilars with the recent
U.S. Food and Drugs Administration (FDA) in the region. The U.S.
contributed largest revenue to the North American as well as global
protein A resin industry. The country is expected to remain the
largest market for protein A resin globally during the forecast
period. This market is expected to witness the highest growth in
Asia-Pacific during the forecast period, owing to the increasing
compliance for biosimilars and shifting global attentiveness for
expanding biopharmaceutical manufacturing capacities in the emerging
economies of the region.
Increasing awareness about random methods to
purify monoclonal antibodies is obstructing the Protein A Resins
market. High costs associated with the Protein A resins is also a
major factor restraining the market growth. Geographic expansion,
agreements, strategic acquisitions, and continuous effort to improve
the product assortment are the key strategies adopted by the market
players to stand the competitive market.
There is an increasing demand for early detection
and prevention of curable diseases especially in the adults. This is
going to be a key opportunity in the market as the percentage of
adult population is increasing on a daily basis owing to the rise in
life expectancy among the global population. The demand for safe and
valuable treatments is gaining prevalence in the market. This factor
coupled with unmet medical needs among the patients will fuel the
growth of the global sickle cell anemia therapeutics market.
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Key players operating in the global protein A
resin market are Thermo Fisher Scientific Inc., General Electric
Company, Merck KGaA, Repligen Corporation, Tosoh Corporation,
Expedeon Ltd., Novasep, and GenScript, among others.
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