Technological advancements to drive growth of the global artificial pancreas device system (APDS) market

Artificial Pancreas Device System (APDS) – Putting the Ease in Diabetes Management
Administering insulin on daily basis is cumbersome for type 1 diabetes (T1D) patients in a busy lifestyle. While devices such as insulin pumps, pens, and jet injectors have made living with diabetes less stressful by ridding users of relatively painful insulin delivering devices such as needles and syringes. Juvenile Diabetes Research Foundation (JDRF) is working in collaboration with many industry players such as Medtronic, Inc., Johnson & Johnson, and Tandem Diabetes Care, Inc. to develop innovative insulin and glucose monitoring systems/devices.
Artificial pancreas is the outcome of these collaborations which is also encouraged for use by the FDA. Artificial pancreas device system (APDS) consists of an insulin pump, sensor, transmitter, and a receiver. MiniMed 530G from Medtronic, Inc. was the first artificial pancreas device system (APDS) approved by FDA. This threshold suspend device system enables temporary suspension of insulin delivery when the glucose level is lower than the threshold level. Another system, Medtrum’s P6 Easy Touch Disposable Pump is a semi-closed loop artificial pancreas that is under clinical trials in Europe. Many such systems are under clinical trials and expected to be launched in near future in the global artificial pancreas device system (APDS) market. Developed economies in North America, Europe and Pacific region would be the potential regional opportunities for this novel system in the global artificial pancreas device system (APDS) market.

Category		Product	Company/Institute	Status	Expected launch
Threshold Suspended Device Systems		t:slim	Tandem	XX	XX
Treat to Range/Control to Range (TTR/CTR)		Animas pump	Animas Corporation	XX	XX
Treat to Target/ Control to Target (TTR/CTT)	Insulin-only	iLet	Beta Bionics	FDA submission by 2017 end	XX
		XX	XX	XX	XX
		XX	XX	XX	XX
	Hybrid systems	MiniMed 670G	Medtronic	FDA Approved	Apr-17
		XX	XX	XX
		XX	XX	XX	XX
	Bi-hormonal systems	iLet	Beta Bionics	FDA submission potentially in 2019.
		XX	XX	XX
		XX	XX	XX

The global artificial pancreas device system (APDS) market was valued at US$ 64.0 million in 2015 and is expected to witness a moderate CAGR of 18.6% during the forecast period (2016 – 2024).
Figure 1. Global Artificial Pancreas Device System (APDS) Market Size and Forecast, US$ Million and Y-o-Y Growth (%), 2014–2024

Source: Coherent Market Insights Analysis (2017)
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Technological advancements to drive growth of the global artificial pancreas device system (APDS) market
In 2016, the U.S. FDA approved a hybrid closed-loop artificial pancreas device system (APDS) MiniMed 670G which is an automated system. The continuous glucose monitor in the system automatically sends signals to the insulin pump to deliver insulin when the glucose level in body goes beyond the acceptable limit. Thus, there is no need for the user to stimulate the release of insulin every time the glucose level is abnormal. This provide the user freedom to perform his/her daily activities. Such advancement in T1D management is expected to be highly preferred by the users and medical community, leading to higher advocacy to use this device especially among the patient group using insulin pumps. Moreover, in mid-2018, a study will test a bihormonal “bionic pancreas” system at the Massachusetts General Hospital (Boston) and Boston University. This would further fuel the artificial pancreas device system (APDS) market growth and attract more investments.
Strategic collaborations fostering artificial pancreas device system (APDS) market growth
There were over 20 projects undertaken by the industry payers in 2015 with respect to development of artificial pancreas device system (APDS). Bigfoot Biomedical acquired Asante’s FDA approved Snap insulin pump technology in 2015 and at the same time signed a development agreement with Dexcom to integrate Dexcom’s CGM in its under development artificial pancreas device system (APDS). Dexcom is in collaboration with many other market players such as Insulet Corporation, Animas Corporation, and International Diabetes Closed Loop wherein, these companies would be incorporating Dexcom’s CGM in their artificial pancreas device system (APDS). Such collaborations are expected to expedite market entry for new artificial pancreas device system (APDS)s and thus drive the growth of artificial pancreas device system (APDS) market.
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Lack of reimbursement to hinder artificial pancreas device system (APDS) market growth
The prevalence of T1D in the U.S. is 1.35 million which is expected to increase to 5 million by 2050 as per the estimates (2016) by JDRF. Each year 40,000 people are diagnosed with T1D in the U.S. according to the JDRF. With this huge patient base, potential opportunity for artificial pancreas device system (APDS) looks considerably high at global level. However, lack of reimbursement for glucose sensors is expected to inhibit the uptake of artificial pancreas device system (APDS). With an average cost of US$ 6000-7000, adoption of artificial pancreas device system (APDS) is estimated to be restricted among rich T1D patients. Furthermore, only a few T1D patient group prefer insulin pumps for treatment. According to the 2013 report of JDRF, about 350,000 insulin pumps were sold in the U.S. Thus, creating awareness should also be an objective of artificial pancreas device system manufacturers to increase its adoption.
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Rheumatoid Arthritis Treatment Market - Global Industry Insights, Trends, Outlook, and Opportunity Analysis, 2016–2024

Rheumatoid Arthritis Treatment Market Overview:
Rheumatoid arthritis (RA) is the most common autoimmune arthritis affecting more than 1.3 million U.S. citizens (American College of Rheumatology). More surprising is to know that around 75% of this affected population is women. Affecting the joints at any age, rheumatoid arthritis needs to be addressed early to avoid expensive joint replacement surgery. While it can affect any joint, small joints in hand and feet tend to be affected the most. Treatments available for rheumatoid arthritis aids to relive symptoms and improve the joint function. A comprehensive treatment for RA usually involves integration of patient education, exercise, medications, and surgery (occasionally). The rheumatoid arthritis treatment market can be analyzed based on the drug type, as follows:

• Biological drugs
• Monoclonal antibodies
• Non-Biologicals
• Non-steroidal Anti-inflammatory Drugs (NSAIDs)
• Corticosteroids
• Analgesics
• Disease-modifying anti-rheumatic drugs (DMARDs)
• IL-6 inhibitors
• TNF inhibitors

NSAIDs and corticosteroid are also the first-line fast acting therapeutic drugs. Acetylsalicylate, naproxen, ibuprofen, etodolac, and diclofenac are the NSAIDs usually prescribed as first-line drugs for RA. These drugs reduce inflammation, and pain. Corticosteroid medications are given either orally or parenterally to reduce inflammation and restore joint mobility and function. These class of drugs are more potent than NSAIDs and therefore usually preferred a first line therapy by prescribers. The global rheumatoid arthritis treatment industry is expected to be driven considerably in near future by DMARDs that form second line slow-acting therapeutic drugs. Longer therapeutic regimen with these drugs increases cost of therapy and also promote remission of joint destruction and deformity. Methotrexate is the most commonly prescribed second line drug for RA and hence, occupies major share in the respective segment of global rheumatoid arthritis treatment market. Tofacitinib (Xeljanz) is the most potential FDA approved Janus kinase (JAK) inhibitor available in the global market of rheumatoid arthritis treatment.
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FDA approved biologic drugs include rituximab (Rituxan, MabThera), abatacept (Orencia), adalimumab (Humira), etanercept (Enbrel), certolizumab (Cimzia), anakinra (Kineret), infliximab (Remicade), golimumab (Simponi), and tocilizumab (Actemra). Besides these approved drugs, biosimilars in pipeline would fuel the rheumatoid arthritis treatment market growth in near future.
Key statistics pertaining to the global rheumatoid arthritis treatment market:
Over time, there is damage to cartilage and mobility function of the affected joint in rheumatoid arthritis patient.

• Affects nearly 1.3 million U.S. population (RheumatoidArthritis.org)
  
• Most common in the age group of 30-60 years
  
• Global prevalence varies in the range of 0.3% to 1% (World Health Organization)
  
• Average annual cost of treatment may go up to US $20,000 (RheumatoidArthritis.org)
  
• According to the Arthritis Foundation, people with RA loose more workdays compared to those affected by any other medical condition
  
• According to a Harvard University study published in the Journal of Global Health (2017), prevalence of rheumatoid arthritis in Southeast Asian countries was 0.4%, 0.42 in western Pacific region, and 0.37% in eastern Mediterranean countries
  

Plethora of research work to introduce effective treatment therapies in the global rheumatoid arthritis treatment market
Introduction of newer therapies are expected to fuel growth of rheumatoid arthritis treatment market in developed nations. Emerging economies are late adapters to new technologies and therapies, thus are potential markets for brands not yet marketed in these countries. The Chinese FDA recently approved Xeljanz for RZ treatment (2017). The product is awaiting approval from the EU. Among the Asian countries, India, China, Pakistan, and Bangladesh had major prevailing rheumatoid arthritis patients as per WHO–ILAR COPCORD (International League of Associations for Rheumatology) (Community Oriented Program for Control of Rheumatic Diseases) studies (2015). Some of the products in pipeline include:

• Antibodies that target collagen II, an important protein in joint cartilage (Researchers at the Department of Immunology, Genetics and Pathology, Uppsala University, Sweden)
  
• Stem cell I.V. therapy developed by Mesoblast Ltd. to treat RA patients unresponsive to TNF drugs (phase 2 trials)
  

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More of such developments by the market players will be a significant contributor towards the growth of global rheumatoid arthritis treatment industry.
Some of the major players in the global rheumatoid arthritis treatment market are Pfizer, Inc., Johnson & Johnson, Abbvie, Inc., F. Hoffmann-La Roche AG, Merck & Co., Inc., and Amgen, Inc.,
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Gastroscopy Devices Market – Global Industry Insights, Trends, Outlook, and Opportunity Analysis, 2016–2024

Gastroscopy Devices Market Overview:

Gastroscopy is a type of endoscopy performed for diagnosis of diseases pertaining to esophagus, stomach, and upper part of small intestine. It is also called upper gastrointestinal endoscopy. It is one of the most important discoveries in the field of medical science. Esophagoscope was also a type of endoscopy that was used for diagnosis and treatment procedures of esophagus. Gastroscopy has replaced esophagoscopes completely. The only difference between esophagoscope and gastroscope is the length of gastroscope that is longer than esophagoscopes. Gastroscopy can also be performed to detect cancers. This procedure is recommended to diagnose problems related to the esophagus or stomach. The device has a light and a camera at the end of the probe that is used to see the esophagus, upper intestine and stomach clearly. It is also used to investigate problems related to swallowing, ulcers, and blockage in esophagus. This procedure allows practitioners to study the mucous membrane of the stomach. Gastroscopy are broadly classified into two types namely diagnostic gastroscopy used to diagnose or confirm diagnosis and treatment gastroscopy for therapeutic purposes. Esophagus cancer is the eighth-most common cancer in the world. As per the report of World Cancer Research Fund International, there were around 456,000 new esophagus cancer cases diagnosed in 2012. Gastroscopy is considered as the most preferred option for screening of esophagus cancer and polyps by most gastroenterologists and thus, the gastrointestinal endoscopy devices market is projected to witness significant traction in the foreseeable future.

High Incidence of Esophageal Cancer Fueling Gastroscopy Devices Market Growth

Esophageal cancer is of two types namely, adenocarcinoma and squamous cell carcinoma. Esophageal cancer can occur due to various reasons such as gene type that includes gene mutations or damage involved in cell divisions. As per results of an independent study, overweight and obesity increases the risk of esophageal cancer by 48% per 5 BMI units. Polyp detection rate of esophagus and stomach depend upon the proportion of mucosal surface diagnosed and correlates to time dedicated for diagnosis. Gastroscopes consist of a flexible tube with a high definition camera at the end of the probe. The quality of camera defines the quality of diagnosis. The long length of device is used to examine the complete length of the esophagus.

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Gastroscopy Devices Market: Drivers and Restraints

The global gastrointestinal endoscopy devices market is expected to be fueled by advancements in endoscopy technology. Key drivers of the market are increasing cases of esophageal cancer and polyps, growing ageing population, family history of cancer, and changing lifestyle. Increasing government initiatives to diagnose and treat early stage cancers are also expected to fuel gastrointestinal endoscopy devices market. For instance, in 2014, The European Society of Gastrointestinal Endoscopy (ESGE) and United European Gastroenterology (UEG) created a community of endoscopy services across Europe, collaborating with each other to provide high quality, safe, accurate, patient-centred and accessible endoscopic care. The lack of awareness, dearth of experienced professionals, lack of reimbursement policies, and increasing cases associated with bio-dirt is expected to hinder growth of the market.

Gastroscopy Devices Market Taxonomy

The gastroscopy devices market is classified on the basis of product type and end user.

On the basis of product type, the global gastroscopy devices market is segmented into the following:

• Flexible Video Gastroscope
• Flexible Non-video Gastroscope

On the basis of end user, the global gastroscopy devices market is segmented into the following:

• Hospitals
• Ambulatory Surgical Centers
• Clinics

Gastroscopy Devices Market: Overview

Technological advancements in gastroscopy technique are expected to drive growth of the market for gastroscopy device, as these significantly improve detection rate as compared to other conventional procedures. Practitioners prefer using flexible gastroscope over non-flexible gastroscopes due to high quality, less breakage problems and high illumination for better imaging provided by the former. Increasing awareness among practitioners of using the advanced gastroscopy over white light traditional gastroscopy is showing a significant growth towards flexible video gastroscopy. Increasing cases of biodirt provides opportunity to gastroscopy manufacturers to introduce products with innovative features to avoid such cases of infections. Hospital end user segment is expected to remain dominant in the market over the foreseeable future.

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Key players operating the gastroscopy devices market include Olympus, Karl Storz, Sono Scape, Endomed, Medigus, Fujifilm Holdings Corporation and Huger.

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Practice Management System (PMS) Market - Global Industry Insights, Trends, Outlook, and Opportunity Analysis, 2016-2024

Practice Management System Market Overview:

Practice management system (PMS) helps manage the daily operations of an organization. These systems find wide application across various verticals in an industry. Increasing investments to upgrade healthcare facilities, especially in developed regions and growth of the healthcare IT industry in developing regions, is creating a highly conducive environment for growth of the practice management systems market. Increasing adoption of PMS has been witnessed in emerging nations such as Indian, China, South Africa, and Brazil, in order to streamline operations and in turn provide better healthcare facilities in these countries. PMS allows for efficient management of health data, patient scheduling, billing process, and referral policies.

Physicians and group organizations need to maintain large amounts of data of day-to-day activities. Practice management system addresses these needs, maintaining critical patient information such as patient demographics, appointment schedule, insurance payer data, billing, and diagnostic and treatment history. Practice management system software are often synchronized with electronic medical record (EMR) or electronic health records (EMR) software for better hospital management.

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Practice Management Systems Market Taxonomy:

The global market is segmented as follows:

Software type:
• Desktop-only software - intended for single or few computer sharing access
• Client-server software - allow multiple users to share and access data, and
• Internet-based software - do need separate server for operation
  Delivery Platform:
• Web-based
• Cloud
• On-premise
  Product Type:
• Integrated
• Standalone
• Components:
• Hardware
• Software
  End Users:
• Physicians
• Pharmacists
• Diagnostic Laboratories

Increasing hospital visiting on the back of rising prevalence of Chronic and Infectious Diseases creating favorable environment for market growth

World Health Organization (WHO) estimates that there would be around 24 million cancer cases globally by 2035. In the U.S., over one-third of the adult population is obese, as revealed by statistics released by Centers for Disease Control and Prevention (CDC) (2016). As obesity is a major predisposing factor to various diseases such as diabetes and other cardiovascular diseases, steep rise in patient population is expected in the near future.
Prevalence of infectious diseases is also on the rise. Moreover, increasing instanced of drug-resistance has mandated physicians to maintain medication history of patient.
Rapid rise in geriatric population: According to WHO, over 2 billion individuals worldwide will be aged 60 years and above by 2050. A detailed report published by CDC projects that by 2030, 20% of the U.S. population would comprise of geriatric people. The report also details that cardiovascular diseases is the leading cause of deaths in adults aged 65 and above in the U.S.

Rapid rise in patients visiting hospitals mandates efficient keeping of patient history and record maintenance, in turn fueling growth of the practice management systems market.

High Installation Cost Hindering Growth in Emerging Economies

The practice management systems market share is mainly concentrated in the U.S. mainly due to presence of dense network of hospitals and existing complex healthcare service management and insurance systems. The healthcare system in the U.S., is very unlike that in other countries. Health Maintenance Organizations (HMOs) and Preferred Provider Organizations (PPOs) have been set up, and thus patients tend to visit multiple physicians. Hence, maintenance of consistence treatment history becomes difficult. The market is also growing in major European countries such as the U.K., France, Germany, Italy, and Spain. The PMS market is yet in its introductory phase in Asia Pacific, Latin America, Africa, and Middle East regions, owing to low diagnosis and treatment rate combined with financial challenges linked with deployment of expensive software systems.

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Key Suppliers in the global practice management systems market: Allscripts Healthcare Solutions, Inc. Henry Schein MicroMD, Athenahealth, Inc., GE Healthcare, NextGen Healthcare Information System LLC, Practice Fusion, McKesson Corporation, Greenway Medical AdvantEgde Healthcare Solutions, MediTouch, and Accumedic Computer Systems.

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Global Nasal Atomizer Devices Market Overview:

Nasal delivery is a choice of treatment or drug delivery for the topical treatment of nasal diseases and paranasal sinuses like sinusitis and allergic rhinitis. Moreover, the nasal route is considered in some cases over the normal oral route owing to rapid absorption and needle-free drug delivery with the effect as desired. Hence, it is also one of the preferred routes for needle-free vaccination and systemic drug delivery. Moreover, this route helps addressing issues related to poor bioavailability, slow absorption, drug degradation and adverse events in the gastrointestinal tract. Atomized nasal medications rapidly absorb across mucosal membranes into the bloodstream, avoiding first-pass metabolism. However, during nasal delivery one needs to take care to protect the delicate lungs from hazardous exposures. Medication in liquid form can be administered via nasal route through inhalers, spray pumps, droppers, nebulizers or atomizers. In atomizers the medication exits the tip as a fine atomized mist resulting in broad coverage of the nasal mucosal with a thin layer of drug.

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Nasal Atomizer Device Types

Nasal atomizers are currently used in the treatment of allergic rhinitis and sinusitis. These devices usually are multi-dose products enabling long-term usage of the device. The nasal atomizers are classified based on the technology/mechanics as gas propelled or electrical. The air or gas controlled technique involves the use of squeezed bottle which when pressed releases the content out of the small nozzle in definite volume. The dose delivered however is highly dependent on the pressure applied while squeezing the bottle. An electronic atomizer on the other hand is devised to release only a defined amount of medication from the nozzle. This makes the use of device more convenient for patients at home.

Kurve Technology had designed and developed a nasal drug delivery device called ViaNase in 2004 that used a controlled particle dispersion method. During that period, Kurve’s technology was the only known technique that delivered chemical formulations via the nose to the paranasal sinuses in clinical testing. Moreover, Kurve’s technology was also designed to be used with multiple drugs.

Accurate Dosing is Essential in Atomization

Since then there have been many new devices being introduced in the market with improving dosage accuracy. Accurate dosing is essential in a nasal atomization device to circumvent any side effects due to overdose. Recently in November 2016, Teleflex Medical Corporation recalled its MAD Nasal Intranasal Mucosal atomization device which contained drug to reverse the action of opioid overdose. The device was recalled on the warning that it may not deliver the proper dose of the drug naloxone hydrochloride. This drug with the device is extensively used by the policemen and firefighters in the U.S.

The market still in its nascent stages of adoption is experiencing increasing acceptance in the developed regions of North America and Europe. However, creating awareness among the healthcare professionals and patients is essential for acceptance of this novel technology. Increasing self-medication trend can be leveraged upon for penetrating the global nasal drug delivery devices market.

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Major market players include DeVilbiss Healthcare, Teleflex Incorporated, and Kurve Technology, etc. Being a niche segment of drug delivery, there exists a lot potential for manufacturers of nasal drug delivery systems.

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Global Nanoparticles Market - Global Industry Insights, Trends, Outlook, and Opportunity Analysis, 2016–2024

Global Nanoparticles Market Overview:

Particles between 1 and 100 nanometers (nm) in size known as nanoparticles. An individual nanoparticle molecule behaves as a complete unit in terms of its property and transportation. Rapidly increasing public awareness for nanotechnology and introduction of new technologies will have many beneficial consequences. Moreover, increasing applications of nanotechnology in drug development and stringent guidelines for developing improved medical products are some of the prime factors which is expected to witness significant growth over the forecasted period. Furthermore, huge capital investment and high cost of nanoparticle analysis instrument is one of the key restraint for the growth of nanoparticle market. Due to its wide applications in healthcare, biomedical, electronics and among others the nanoparticle is currently a new area of research among many scientist. Rising government spending on pharmaceuticals and bio technology research and development and increasing focus on nanotechnology research also expected to experience significant growth. North America dominated the global nanoparticles market due to increasing chronic diseases such as diabetes, cardiovascular and cancer. Moreover, Europe is expected to witness the highest growth during the forecasted period, due to rapid research and development for nanoparticles. However, due to rampant economic growth of China and India, Asia Pacific is also expected to witness decent growth during the forecasted period. Furthermore, India is also an emerging hub for pharmaceuticals research and development.

Nanoparticles Market Taxonomy

On the basis of technology, the global market is classified into:

Liposomes

Nanotubes

Polymeric nanoparticles

Polymer conjugated drugs

Dendrimers

Inorganic nanoparticles

Others

On the basis of end user, the global market is classified into:

Pharmaceuticals industry

Biochemical industry

Research institutions

others

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Nanoparticles Market Outlook – Surge in Drug Development in Pharmaceuticals Industry Augmenting Market Growth

Expansion of medical diagnostic industry and wide application of nanotechnology in healthcare sector such as neurology, cardiology and anti-infective is estimated to have a decent growth for nanoparticles market in the forecast period. Depending upon preparation methods nanoparticles, nanocapsules or nanospheres can be obtained. A long circulating particle made up of Biodegradable polymeric nanoparticles with hydrophilic polymer coating of poly ethylene glycol (PEG), used as a powerful drug delivery device. Due to its ability to deliver peptides, proteins and genes, it is also used as a DNA carrier in gene therapy. Numerous advantages for nanoparticles in drug delivery system is expected to Spector enormous growth during the forecasted period. Moreover, growing public awareness, improved technology and increase in chronic diseases escalate the global nanoparticles industry in North America. Emerging economy of Asia Pacific, such as China and India is expected to witness significant growth over the forecasted period.

Nanoparticles Market Challenges – Huge Capital Investment needed in Research and Development

Huge capital investment for research and development of new product and technology. Moreover, high cost of nanoparticles analysis instruments is expected to be one of the key restraints for global nanoparticles market.

Nanoparticles Market – Regulatory Scenario:

• August, 2015, U.S. Food and Drug Administration (FDA), issued guidance to address various issues related to the use of nanotechnology in food ingredients intended for use in food for animals.
• June, 2014, U.S. Food and Drug Administration (FDA), issued three guidelines related to the use of nanotechnology in regulated products, including cosmetics and food substances.

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Some of the key players in the market includes Abraxis Biosciences, Inc., Novartis International AG, Gilead Sciences, Inc., Johnson & Johnson, Sigma-Tau Pharmaceuticals, Inc. Amgen, Inc., and Nano Interface Technology, Inc., Malvern Instruments Ltd., Horiba Ltd., Beckman Coulter, Shimadzu Corporation, Agilent Technology Inc, Hitachi Ltd., Wyatt Technology, among others.

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B-Cell Maturation Antigen (BCMA) Targeted Therapies Market - Global Industry Insights, Trends, Outlook, and Opportunity Analysis, 2016-2024

BCMA Targeted Therapies market Overview:

Multiple myeloma is an incurable disease of plasma cells, which needs some intervention by clinical researchers. However, there have been recent success in developing such therapy that can be effective in hematologic malignancies such as chimeric antigen receptor CAR-T cell therapy, which is expected to be promising in cancer treatment. However, researchers have found little success in finding a specific target antigen under CAR T-cell therapies for treating multiple myeloma. Though, there have been recent studies that suggest a targeted effect of B-cell maturation antigen (BCMA) that has been effective in cells with multiple myelomas. BCMA is a protein, which is selectively expressed by B-lineage cells that directly work on cells with multiple myelomas. Researchers are still working to determine the compatibility in target for CAR-expressing T cells for BCMA. Furthermore, B-cell maturation antigen (BCMA) is a vital biomarker of the B-cells that is a promising and newly emerged therapeutic target to treat multiple myeloma and other hematological malignancies.

Multiple myeloma affected cells are considered to be having B-cell maturation antigen. This has led to various studies related to BCMA targeted therapies in the recent past. Multiple myeloma is the second-most common type of hematological malignancy, which affects a large population. According to the American Cancer Society, in 2017, around 30,280 new cases are estimated to be diagnosed, leading to around 2,600 deaths. Middle-aged men exposed to any type of radiation or chemicals a past history of monoclonal gammopathy of undetermined significance (MGUS) are most at risk of contracting multiple myeloma. Increasing awareness among the research community and renewed efforts across the globe to effectively treat cancer and related diseases is expected to provide major traction for growth of the BCMA targeted therapies market in the foreseeable future.

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BCMA Targeted Therapies Market Taxonomy:

By Product Type

• CAR-T cells
• Bispecific Antibodies
• Antibody Drug Conjugates

By End User

• Hospitals
• Cancer Research Institutes

Increase in prevalence of multiple myeloma globally is expected to support growth of BCMA targeted therapies market:

Multiple myeloma can be fatal and is linked with frequent events of re-occurrence of the disorder along various other serious complications associated with it. The globally widespread prevalence of the disorder and B-cell malignancies needs specific and targeted diagnosis and treatments. Hence, there is an immediate requirement for targeted and effective therapies to provide appropriate medical care. This in turn is expected to favor growth of BCMA market in the near future. Multiple myeloma is characterized by the clonal proliferation of plasma cells in bone marrow, which leads to bone destruction, renal abnormalities, anemia and hypercalcemia. The rise in prevalence of multiple myelomas in the population around the globe is projected to underpin the growth expansion of targeted therapies in BCMA market in the near future. According to National Institutes of Health and National Cancer Institute, in 2013, in the U.S., there were around 96,000 people living with myeloma.

Specificity and targeted effect on cancer cells is projected to favor growth of the BCMA targeted therapies market

B cell maturation antigen, is the member of the tumor necrosis factor receptor group and a type III membrane protein containing one extracellular cysteine rich domain, which has been designated as TNFRSF17. The specificity of the therapy to treat the patients affected from multiple myelomas is projected to be one of the vital factors favoring growth in adoption of B-Cell Maturation Antigen targeted therapies in the near future. Furthermore, collaboration between the existing players in the B-Cell Maturation Antigen market is expected to be one of the crucial factor in its growth, this will further expected to enhance the company’s product portfolio over the forecast period.

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Key players operating in the BCMA targeted therapies market include Celgene Corporation, bluebird bio, Poseida Therapeutics, Inc., Juno Therapeutics, Eureka Therapeutics,

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Erectile Dysfunction Market to Surge Past US$ 4.3 Billion by 2024 with North America Positioned as Growth Engine

The Global Erectile Dysfunction Market was valued at US$ 4,129.5 million in 2015 and is projected to expand at a CAGR of 0.2% during the forecast period (2016–2024),as highlighted in a new report published by Coherent Market Insights. Growing prevalence of sexual disease and increasing geriatric population are major factor expected to drive growth of the global erectile dysfunction market.

Erectile dysfunction was earlier believed to be a condition mainly prevalent among elderly men. However, a recent study conducted by medical institution across the globe, explains that the erectile dysfunction also affects younger men, due to sex hormone imbalance at the early stage of their puberty. There are many medications available to treat erectile dysfunction that are especially effective among young men, as they are can easily absorb the drugs content and show quick effects when compared to men aged above 60 years.Erectile dysfunction may involve several different medical conditions of reproductive health and sexual dysfunction. Attaining an erection is a one of the multipart process which involves the brain, sex hormones, nerves, muscles, and blood circulation and any deviation or interference from the normal erection process may lead to erectile dysfunction. In some cases at older age of 55-60 years, ED shows a multiple health problem such as cardiovascular problems, which necessitates immediate treatment, as this may also cause a risk factors for heart attacks and strokes.

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Globally around 5% of male who are aged 40 years have a strong or complete erectile dysfunction, and this increases to around 15% of males aged 70 years. Nearly 10% of men in the age group of 50–70 years suffer mild or moderate erectile dysfunction in their life. According to Medical Journal of Sexual Medicine, erectile dysfunction can occur at any age, though it is more prominent among men aged above 60 years. People over 60 years suffer from large number of health conditions when compared to young people and with the weak immune system, any hindrance in hormonal process may need medication, further leads to sexual inability. Moreover, as men age, the erectile stimulation and sexual ability becomes weak. Medication such as Cialis and Viagra are highly prescribed drugs in the erectile dysfunction market.

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Increasing prevalence of male sexual dysfunction in the highly populous Asia region is a major factor driving growth of the erectile dysfunction market. For instance, in 2011, the prevalence percentage of erectile dysfunction in China was 45%, South Korea 32.3%, Malaysia 26.8%, Thailand 37.5%, and Singapore 51.5%. According to UK Health Center, 1 in 10 men worldwide suffer from erectile dysfunction and more than half of all diabetic men suffer from erectile dysfunction. Over 20 million people globally are prescribed Viagra to treat erectile dysfunction, and out of this 66% of people who are administered or prescribed Viagra, are able to have sexual intercourse. Around 48% of this group suffer from one or more side-effects from Viagra.

Key takeaways of the erectile dysfunction market:

• The global erectile dysfunction market is expected to expand at a CAGR of 0.2% during the forecast period (2016–2024) as there still exists a major unrealized market, especially in Africa and Middle East countries.
• The Cialis product dominates the erectile dysfunction market in by product segment as it is the primary drug prescribed by many physicians globally because of high therapeutic efficacy and lower price

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• Some of the major players involved in global erectile dysfunction market are Meda Pharmaceuticals, Inc, Coloplast, Global Life Technologies, Reflexonic, LLC, Augusta Medical System, Boston Scientific Corporation, and Vivus, Inc.

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Ostomy Drainage Bags Market – Global Industry Insights, Trends, Outlook, and Opportunity Analysis, 2016–2024

Ostomy Drainage Bags Market Overview:

Ostomy is a surgery to make an opening or stoma from a locale present in the interior of the body to the exterior. It predominantly treats diseases related to urinary or digestive systems. Ostomy may be permanent or temporary. In some cases an organ must be detached or removed, which is a permanent condition. However, when the organ or the specific part inside the body heals with time, and is not removed, the ostomy is temporary. The organ may be the colon, the small intestine, bladder or rectum. Whenever an ostomy is performed, wastes must be led outside the body through various procedures. This process of draining the wastes out of the body is known as ostomy drainage. The disposal bag used for this process is called ostomy drainage bag. After the ostomy procedure, bowel movements take place through the opening or stoma in the abdominal. This appliance has a bag and wafer. The wafer attaches to the abdominal wall with the help of an adhesive and the material is made of plastic.  The primary function of the bag is to retrieve and retain the stool. Ostomy drainage bags are disposable and are replaced or emptied as required.

According to National Institute of Diabetes and Digestive and Kidney Diseases, ostomy is broadly divided into three types - Ileostomy, Colostomy, and Urostomy. In Ileostomy, the base of the ileum or small intestine is attached to the opening or stoma. This goes around the anus, colon, and rectum. In colostomy, the colon is linked with the stoma, thereby bypassing the anus and rectum. In urostomy, the pipes that carry urine are linked to the stoma, which helps in bypassing the bladder.

Increasing awareness about ostomy procedure is one of the key factors that will propel the growth of the ostomy drainage bags market. Moreover, increasing incidence of Crohn’s disease and IBD (inflammatory bowel disease) would further propel growth of market in the foreseeable future.

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Ostomy Drainage Bags Market Taxonomy

On the basis of product type, the global market is classified into:

• Colostomy Bags
• Urostomy Bags
• Ileostomy Bags

On the basis of type of use, the global market is classified into:

• Single-use Ostomy Drainage Bags
• Multi-use Ostomy Drainage Bags Diagnostics

Due to factors such as increased awareness about colostomy, soaring incidence of colorectal cancer, and a variety of buying options for colostomy bags, the colostomy bags segment accounted for the largest share of the overall ostomy drainage bags market. According to American Cancer Society’s estimates, colorectal cancer is the third-most common cancer diagnosed in the U.S., with 95,520 new cases of colon cancer and 39,910 new cases of rectal cancer reported in the country in 2016. Increasing prevalence of colostomy and rectal cancer would necessitate ostomy, which in turn would drive overall growth of the ostomy drainage bags industry.

Growing geriatric population and increasing prevalence of ulcerative colitis creates large addressable market for ostomy drainage bags

In the recent past, prevalence of ulcerative colitis and IBD, especially among the geriatric population has increased significantly. Inflammatory bowel disease is common in developed countries, with higher prevalence in urban areas. Urbanization is a factor that might contribute to the increasing occurrence of the disease. However, with urbanization and rise in per capita income, the healthcare spends also increase proportionately. This will ensure timely and speedy recovery of the patients suffering from IBD and ulcerative colitis; thereby driving growth of the market.

North America held the largest share of the global ostomy drainage bags market, owing to high patient awareness and large geriatric population. However, Asia Pacific is projected to demonstrate high growth rates during the forecast period. India and China are projected to grow significantly in the global market for ostomy drainage bags in the Asia-Pacific region. Chief driving factors for the growth of industry in this region are increasing healthcare expenditure and presence of a large pool of patients.

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Some of the companies operating in the ostomy drainage bags market in the current scenario are Salts Healthcare Ltd., Welland Medical Ltd., Pelcin Healthcare Ltd., ConvaTec Inc., Hollister Incorporated, Coloplast A/S, Alcare Co Ltd, and B. Braun Melsungen AG.

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Human Microbiome Market - Global Industry Insights, Trends, Outlook, and Opportunity Analysis, 2016–2024

Human Microbiome Market Overview:

Microbial cells outnumber the human cells in the ratio 10:1 in a health human body. Human microbiome is the study of microbes present in the human body. These are beneficial microbes that carry out functions not performed by any gene in the human DNA and hence, they play a very important role in the human body. For example, these microbes produce certain vitamins that our body cannot make, breakdown our food, equip our immune system to recognize harmful foreign bodies, and produce anti-inflammatory compounds against it. The seemingly unending beneficial properties of microbial population was unearthed in 2008, as part of the Human Microbiome Project (HMP) launched by the National Institutes of Health (NIH). The HMP project aims to characterize the human microbiome and analyze its role in human health and disease conditions.

The HMP has identified microbiome communities at several human body sites, including gastrointestinal tract, skin, oral cavity, nasal passages, and urogenital tract. Currently, the HMP projects are focused on three areas – pregnancy and preterm birth, onset inflammatory bowel disease, and onset of type 2 diabetes.

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Global Human Microbiome Market Taxonomy

Research in this field has led to the emergence of various microbiome-based products. The global human microbiome market is analyzed on the basis of product type into probiotics, prebiotics, foods, medial foods, diagnostic devices, and other drugs and supplements. Prebiotics are increasing demand worldwide, with growing awareness about the various beneficial properties of the product such as improved digestion, better gut health, help with weight loss, and reduced risk of heart disease.

On the basis of application, the global human microbiome market is segmented into therapeutic and diagnostic. Therapeutic use of human microbiome is increasing with research yielding new applications and usage of human microbiome. The market is thus expected to be inclining towards therapeutic applications in near future. Moreover, microbiome products are considered to be relatively safe, which creates a highly conducive environment for growth of human microbiome industry.

The human microbiome can also be analyzed based on the technology used for conducting research in this field. These technologies include cell culture technology, high-throughput technology, omics technology and computational tools. Products used for research include instruments (analyzers and other laboratory instruments) and consumables (kits and reagents).

Market participants can also understand the human microbiome market dynamics through analysis for different health conditions such as obesity, diabetes, acute diarrhea, mental disorders, autoimmune disorders, cancer, and other diseases.

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Human microbiome market: Regional overview

The human microbiome market is in growth stage and is rapidly emerging, with promising future. The market is highly developed in North America and Europe, where product and technology is high among the consumers, researchers and healthcare practitioners. Introduction of new products and microbiome modulators in these regions would propel market growth. There is high interest in incorporating microbiome modulators in food and dietary supplements of human diet in order to supply the body with the missing dietary supplements. The human microbiome technology and products would gain significant traction in the emerging economies of Asia Pacific, Latin America, and Middle East regions. Growing product awareness, rising demand for safe medical products and increasing research activities would be the driving factors for human microbiome industry in these regions.

Some of the key players in the global human microbiome market include Merck & Co. Inc., Affymetrix Inc., Vithera Pharmaceuticals, Microbiome Therapeutics, LLC, Vedanta Biosciences, Inc., Metabiomics Corporation, Enterome Bioscience, Osel, Inc., Yakult Honsha Co., Ltd., Second Genome, Inc. and E.I. Du Pont De Nemours and Company

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Global Nanoparticles Market - Global Industry Insights, Trends, Outlook, and Opportunity Analysis, 2016–2024

Global Nanoparticles Market Overview:

Particles between 1 and 100 nanometers (nm) in size known as nanoparticles. An individual nanoparticle molecule behaves as a complete unit in terms of its property and transportation. Rapidly increasing public awareness for nanotechnology and introduction of new technologies will have many beneficial consequences. Moreover, increasing applications of nanotechnology in drug development and stringent guidelines for developing improved medical products are some of the prime factors which is expected to witness significant growth over the forecasted period. Furthermore, huge capital investment and high cost of nanoparticle analysis instrument is one of the key restraint for the growth of nanoparticle market. Due to its wide applications in healthcare, biomedical, electronics and among others the nanoparticle is currently a new area of research among many scientist. Rising government spending on pharmaceuticals and bio technology research and development and increasing focus on nanotechnology research also expected to experience significant growth. North America dominated the global nanoparticles market due to increasing chronic diseases such as diabetes, cardiovascular and cancer. Moreover, Europe is expected to witness the highest growth during the forecasted period, due to rapid research and development for nanoparticles. However, due to rampant economic growth of China and India, Asia Pacific is also expected to witness decent growth during the forecasted period. Furthermore, India is also an emerging hub for pharmaceuticals research and development.

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Nanoparticles Market Taxonomy

On the basis of technology, the global market is classified into:

• Liposomes
• Nanotubes
• Polymeric nanoparticles
• Polymer conjugated drugs
• Dendrimers
• Inorganic nanoparticles
• Others

On the basis of end user, the global market is classified into:

• Pharmaceuticals industry
• Biochemical industry
• Research institutions
• others

Nanoparticles Market Outlook – Surge in Drug Development in Pharmaceuticals Industry Augmenting Market Growth

Expansion of medical diagnostic industry and wide application of nanotechnology in healthcare sector such as neurology, cardiology and anti-infective is estimated to have a decent growth for nanoparticles market in the forecast period. Depending upon preparation methods nanoparticles, nanocapsules or nanospheres can be obtained. A long circulating particle made up of Biodegradable polymeric nanoparticles with hydrophilic polymer coating of poly ethylene glycol (PEG), used as a powerful drug delivery device. Due to its ability to deliver peptides, proteins and genes, it is also used as a DNA carrier in gene therapy. Numerous advantages for nanoparticles in drug delivery system is expected to Spector enormous growth during the forecasted period. Moreover, growing public awareness, improved technology and increase in chronic diseases escalate the global nanoparticles industry in North America. Emerging economy of Asia Pacific, such as China and India is expected to witness significant growth over the forecasted period.

Nanoparticles Market Challenges – Huge Capital Investment needed in Research and Development

Huge capital investment for research and development of new product and technology. Moreover, high cost of nanoparticles analysis instruments is expected to be one of the key restraints for global nanoparticles market.

Nanoparticles Market – Regulatory Scenario:

• August, 2015, U.S. Food and Drug Administration (FDA), issued guidance to address various issues related to the use of nanotechnology in food ingredients intended for use in food for animals.
• June, 2014, U.S. Food and Drug Administration (FDA), issued three guidelines related to the use of nanotechnology in regulated products, including cosmetics and food substances.
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Some of the key players in the market includes Abraxis Biosciences, Inc., Novartis International AG, Gilead Sciences, Inc., Johnson & Johnson, Sigma-Tau Pharmaceuticals, Inc. Amgen, Inc., and Nano Interface Technology, Inc., Malvern Instruments Ltd., Horiba Ltd., Beckman Coulter, Shimadzu Corporation, Agilent Technology Inc, Hitachi Ltd., Wyatt Technology, among others.

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Veterinary Vaccines Market To Surpass US$ 9.4 Billion By 2024

The Global Veterinary Vaccines Market was valued at US$ 5,688.7 million in 2015 and is projected to expand at a CAGR of 5.9% during the forecast period (2016–2024), as highlighted in a new report published by Coherent Market Insights.Rise in incidence of food-borne zoonotic diseases along with increase in population of livestock is expected to favor growth of the veterinary vaccines market. According to European food safety authority (EFSA), In the European Union (EU), over 320,000 fatalities are reported each year due to food-borne zoonotic diseases.

Zoonoses are infections that directly infect humans or are indirectly transmitted to humans through animals by transmission of micro-organisms such as such as bacteria and their toxins, viruses and parasites. This can be caused due to consumption of contaminated food in contact with infected animals or contaminated meat products. Severity of such diseases varies from mild symptoms to life-threatening conditions. Most such micro-organisms are found in the intestines of healthy food-producing animals. The above concern is one of the major factors projected to propel growth of the market for veterinary vaccines over the forecast period. Furthermore, livestock animals serve as a major source of primary and secondary food products. Rise in population of livestock animals is expected to fuel demand for veterinary vaccines in the near future. Veterinary vaccines promotes better growth of animals. According to WHO, in 2015, children under five years of age accounted for one third of all deaths due to foodborne diseases.

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Breakout of zoonotic diseases are dependent on various factors such as environmental changes, demographics related to human and animals, pathogen changes and farming practice modifications. According to Maine Center for Disease Control & Prevention, in 2013, around 75% diseases of animal origin affecting humans were infectious diseases. As animals are the closest companions to humans and also serve as sources of various products such as meat and milk, care should be given according to the severity of the disease from which they can be affected. The specificity of the vaccines is the most important factor that is responsible for the growth in demand for the veterinary vaccines that can be used as prophylaxis. According to clinical microbiology paper published in 2007, veterinary vaccines comprise around 25%of the animal health products globally. Growth for veterinary vaccines industry has grown consistently supported by various factors such as new technological advancements and introduction of novel vaccine development methods for cost effective products, which further favors the rise in availability and adoption rate for the veterinary vaccines globally. Also, drug resistance to existing pathogens and new diseases is also prompting focus on new drug discoveries.

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According to (American Veterinary Medical Association) JAVMA News in 2017, there have been various acquisitions and mergers in veterinary vaccines market in the recent past. However, 85 to 95% of veterinary hospitals in the U.S. are owned independently. Mars Incorporated—a company involved in manufacturing of Petcare, Chocolate, Wrigley, Food and Drinks—is to acquire VCA Inc. – a pet health care services provider in the U.S. and Canada that delivers through nearly around 800 small veterinary hospitals – in total value of around US$ 9.1 billion . Furthermore, in recent years a trend of consolidation has been observed in the industry, as companies are experiencing focusing on leveraging potential through economies of improved business practices. Furthermore, there are various other factors responsible for significant growth in the veterinary vaccines market such as rise in swine population globally and increasing the reach for swine influenza virus globally is projected to favor the market for veterinary vaccines market over the forecast period.

Key takeaways of the market:

• The global veterinary vaccines market is expected to expand at a CAGR of 5.9% during the forecast period (2016–2024). Rise in pet vaccination awareness among the population globally is expected to favor the market for veterinary vaccines market over the forecast period.
• The live attenuated vaccines segment in the global veterinary vaccines market was estimated to be the largest in 2015 and is expected to dominate the market throughout the forecast period in terms of value. Rise in demand for white meat in North America and Europe is expected to fuel the market to high growth over the forecast period
• In terms of animal type, the livestock type sub-segment is expected to expand at a significant CAGR of 5.6% during the forecast period owing to rise in population of livestock animal and the human dependency on the cattle for primary as well as secondary products
• The global veterinary vaccines market is characterized by strategic research and development and advancements in the technology of vaccines production. Also, the rise in adoption for poultry business globally is expected to favor the market for veterinary vaccines market.
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• Some of the major players are Zoetis Inc. Merck Animal Health, Merial Inc., Boehringer Ingelheim, Bayer Animal Health, Elanco Animal Health, Ceva Animal Health, Heska Corporation, Virbac Inc., and Indian Immunological Ltd.

About Coherent Market Insights:

Coherent Market Insights is a prominent market research and consulting firm offering action-ready syndicated research reports, custom market analysis, consulting services, and competitive analysis through various recommendations related to emerging market trends, technologies, and potential absolute dollar opportunity.

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